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Related Experiment Video

Updated: Jun 6, 2026

High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum

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Published on: November 23, 2013

CDR2 antigen and Yo antibodies.

Cecilie Totland¹, Nina K Aarskog, Tilo W Eichler

¹Department of Neurology, Haukeland University Hospital, Bergen, Norway.

Cancer Immunology, Immunotherapy : CII

|November 17, 2010

Summary

Yo antibodies, linked to paraneoplastic cerebellar degeneration (PCD), were studied in ovarian cancer. Findings suggest antibody production involves immune dysregulation beyond just CDR2 protein expression.

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Published on: September 15, 2016

Area of Science:

Neuroimmunology
Oncology
Molecular Biology

Background:

Paraneoplastic cerebellar degeneration (PCD) is an autoimmune disorder often associated with Yo antibodies.
Yo antibodies target the cerebellar degeneration-related protein 2 (CDR2).
These antibodies can be present in ovarian cancer patients even without PCD.

Purpose of the Study:

To investigate the association between Yo antibody production and variations in CDR2 gene sequence, mRNA, or protein expression in ovarian cancers.
To explore the role of CDR2 expression levels in the development of Yo antibody-related paraneoplastic syndromes.

Main Methods:

Analysis of CDR2 cDNA sequence, mRNA levels, and protein expression in ovarian cancer tissues.
Comparison of CDR2 expression in tumors with and without associated Yo antibodies.
Detection of CDR2 in various cancer types and normal ovarian tissue.

Main Results:

No significant differences were observed in CDR2 cDNA sequence, mRNA, or protein levels between ovarian cancers with and without Yo antibodies.
CDR2 expression was detected in multiple cancer types and normal ovarian tissues.
The presence of Yo antibodies appears independent of CDR2 expression levels alone.

Conclusions:

Yo antibody production in paraneoplastic syndromes is likely influenced by factors beyond CDR2 expression, suggesting a role for immune dysregulation.
Further research is needed to elucidate the mechanisms driving Yo antibody generation in the context of ovarian cancer.