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Related Concept Videos

Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
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Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
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Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
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Chronic Kidney Disease III: Interprofessional Care

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Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
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Implementing a collaborative protocol in a sepsis intervention program: lessons learned.

Brian Casserly1, Michael Baram, Patricia Walsh

  • 1Memorial Hospital of Rhode Island, Brown University, 111 Brewster Street, Pawtucket, RI 02860, USA. brian_casserly@brown.edu

Lung
|November 17, 2010
PubMed
Summary
This summary is machine-generated.

Implementing a sepsis intervention program improved patient care processes in the Emergency Department (ED) and Medical Intensive Care Unit (MICU). However, the program was underutilized, with less than half of eligible sepsis patients completing the protocol.

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Last Updated: Jun 6, 2026

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Area of Science:

  • Critical Care Medicine
  • Hospital Quality Improvement
  • Patient Care Protocols

Background:

  • Severe sepsis and septic shock require timely and standardized interventions.
  • Effective sepsis management necessitates collaboration between emergency and intensive care units.
  • Previous experience with specific sepsis intervention programs was lacking in the study setting.

Purpose of the Study:

  • To evaluate the impact of a Sepsis Intervention Program on patient care processes.
  • To assess the collaborative effectiveness between the Emergency Department (ED) and Medical Intensive Care Unit (MICU) in sepsis management.
  • To determine the utilization rate of a sepsis intervention protocol in a tertiary-care hospital.

Main Methods:

  • Prospective cohort study involving 87 severe sepsis or septic shock patients.
  • Implementation of a sepsis intervention protocol after a 3-month staff training period.
  • Data collection on process measures (e.g., fluid administration, central venous access, antibiotics, vasopressors) and outcomes (mortality, length of stay).

Main Results:

  • The sepsis intervention protocol was initiated in 76% of eligible patients but only completed by 48%.
  • Significant improvements were observed in key processes of care, including timely fluid administration, central venous access, and antibiotic delivery.
  • In-hospital mortality was 30.5%, similar to landmark studies, with no significant improvement in secondary outcomes like length of stay or mortality.

Conclusions:

  • A sepsis intervention program can enhance patient care processes in a standard hospital setting.
  • Despite collaborative efforts, the sepsis intervention protocol demonstrated underutilization.
  • Further strategies are needed to improve adherence and completion rates for sepsis protocols.