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Related Experiment Videos

Postpartum thyroid dysfunction and HLA status.

M Kologlu1, H Fung, C Darke

  • 1Department of Medicine, King's College Hospital Medical School, London.

European Journal of Clinical Investigation
|February 1, 1990
PubMed
Summary
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Women with antithyroid antibodies are at higher risk for postpartum thyroid dysfunction (PPTD). Specific human leukocyte antigen (HLA) combinations were significantly more common in women who developed PPTD.

Area of Science:

  • Immunogenetics
  • Reproductive Endocrinology
  • Autoimmune Diseases

Background:

  • Postpartum thyroid dysfunction (PPTD) affects women after childbirth.
  • Antithyroid antibodies are markers of autoimmune thyroid disease.
  • The genetic predisposition to PPTD is not fully understood.

Purpose of the Study:

  • To investigate the association between human leukocyte antigen (HLA) haplotypes and the development of postpartum thyroid dysfunction (PPTD).
  • To determine if specific HLA combinations increase the risk of PPTD in women with antithyroid antibodies.

Main Methods:

  • Prospective study of 901 pregnant women tested for antithyroid antibodies.
  • HLA typing performed on 113 antibody-positive women and 108 antibody-negative controls.

Related Experiment Videos

  • Women followed through pregnancy and 12 months postpartum for PPTD development.

    • Main Results:

    • Forty-five women developed PPTD, with 36 being antibody-positive.
    • Significant increase in HLA B8, DR3 (40.0%) and HLA A1, B8, DR3 (35.6%) in women with PPTD compared to controls (P < 0.02 and P < 0.01, respectively).
    • These HLA haplotypes are associated with other organ-specific autoimmune diseases.

    Conclusions:

    • Specific HLA haplotypes (HLA B8, DR3 and HLA A1, B8, DR3) are significantly associated with an increased risk of developing postpartum thyroid dysfunction (PPTD).
    • Findings support the role of autoimmune mechanisms in the pathogenesis of PPTD.
    • Genetic factors, particularly certain HLA combinations, play a role in susceptibility to PPTD.