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The CRP genotype, serum levels and lung function in men: the Caerphilly Prospective Study
Charlotte E Bolton1, Wiebke Schumacher, John R Cockcroft
1Wales Heart Research Institute, School of Medicine, Cardiff University, Heath Park, Cardiff, Wales, UK. charlotte.bolton@nottingham.ac.uk
Clinical Science (London, England : 1979)
|November 18, 2010
Summary
Systemic C-reactive protein (CRP) is linked to reduced lung function. However, this study found no causal link via CRP gene variants, suggesting other factors influence this association.
Area of Science:
- Pulmonary Medicine
- Genetics
- Epidemiology
Background:
- Systemic C-reactive protein (CRP) is associated with impaired lung function.
- Establishing a causal link could enhance CRP's diagnostic and therapeutic utility.
- Mendelian randomization is a robust method for investigating causality.
Purpose of the Study:
- To determine if circulating C-reactive protein (CRP) causally affects lung function.
- To assess the association between CRP, lung function parameters (FEV1, FVC), and CRP polymorphisms.
- To investigate causality using Mendelian randomization.
Main Methods:
- Utilized data from the Caerphilly Prospective Study, including 2173 men.
- Measured spirometric lung function (FEV1, FVC) at baseline and follow-up.
- Analyzed serum CRP levels and three CRP polymorphisms (rs1800947, rs1130864, rs1205) using haplotype analysis.
Main Results:
- Serum CRP levels showed an inverse association with contemporaneous and follow-up FEV1 and FVC.
- Serum CRP was also associated with FEV1 decline.
- CRP polymorphisms predicted serum CRP levels but were not clearly associated with lung function or its decline.
Conclusions:
- Serum CRP is cross-sectionally associated with lung function.
- CRP gene polymorphisms do not appear to influence lung function or its decline.
- The observed CRP-lung function relationship may be due to reverse causality, unmeasured confounding, or a modest causal effect.
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