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Updated: Jun 6, 2026

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

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Published on: May 30, 2019

Modelling knowlesi malaria transmission in humans: vector preference and host competence.

Laith Yakob¹, Michael B Bonsall, Guiyun Yan

¹Program in Public Health, College of Health Sciences, University of California, Irvine, CA 92697, USA. laith.yakob@uq.edu.au

Malaria Journal

|November 18, 2010

Summary

Plasmodium knowlesi malaria can spread from humans to mosquitoes, potentially becoming a public health concern. Mathematical modeling shows human adaptation can drive this zoonotic disease transmission.

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Area of Science:

Epidemiology
Evolutionary Biology
Parasitology

Background:

Plasmodium knowlesi, a malaria parasite of macaques, is increasingly found in humans in Southeast Asia.
While humans can be infected, their role in sustaining mosquito transmission of P. knowlesi is not well understood.

Purpose of the Study:

To assess the impact of human host competency on P. knowlesi transmission dynamics.
To explore how differential host competency between humans and macaques influences P. knowlesi spread.

Main Methods:

Utilized a mathematical model adapted for vector-borne diseases.
Employed evolutionary invasion analysis to study host-parasite interactions.

Main Results:

An increasing human population in endemic areas may select for vectors and parasites that favor human-to-human transmission.
Threshold conditions were identified for P. knowlesi to become a significant public health issue.

Conclusions:

Malaria vector-parasite co-evolution, influenced by human activity, is key to understanding P. knowlesi emergence.
Identified conditions highlight the potential for this zoonotic malaria to become a major public health concern.