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Updated: Jun 6, 2026

Detection of Copy Number Alterations Using Single Cell Sequencing
09:45

Detection of Copy Number Alterations Using Single Cell Sequencing

Published on: February 17, 2017

Control-free calling of copy number alterations in deep-sequencing data using GC-content normalization

Valentina Boeva1, Andrei Zinovyev, Kevin Bleakley

  • 1Institut Curie, INSERM, U900, Paris, France. freec@curie.fr

Bioinformatics (Oxford, England)
|November 18, 2010
PubMed
Summary

We developed FREEC, a tool for copy number alteration (CNA) detection in cancer studies using deep-sequencing data. It addresses challenges like missing control samples and polyploidy, enabling accurate CNA calling.

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