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Related Experiment Videos

Thyroid function and treatment in premenstrual syndrome.

T F Nikolai1, G M Mulligan, R K Gribble

  • 1Department of Endocrinology, Marshfield Clinic, Wisconsin 54449.

The Journal of Clinical Endocrinology and Metabolism
|April 1, 1990
PubMed
Summary

This study found no thyroid dysfunction in women with premenstrual syndrome (PMS). Levothyroxine (L-T4) therapy was no more effective than placebo for treating PMS symptoms.

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Area of Science:

  • Endocrinology
  • Women's Health
  • Reproductive Medicine

Background:

  • Previous research suggested a link between premenstrual syndrome (PMS) and thyroid hypofunction (TH), with L-T4 therapy reportedly relieving symptoms.
  • This hypothesis proposed subclinical hypothyroidism as a common cause of PMS.

Purpose of the Study:

  • To investigate thyroid function in women diagnosed with PMS.
  • To evaluate the efficacy of levothyroxine (L-T4) therapy in managing PMS symptoms compared to a placebo.

Main Methods:

  • A double-blind, placebo-controlled study was conducted.
  • Thyroid function tests (T4, T3 uptake, T3, TSH, TRH stimulation test) were performed on 15 normal women and 44 women with PMS.
  • 22 PMS women received L-T4 (1.6 mcg/kg/day), and 22 received a placebo for 2 months.

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Main Results:

  • No significant evidence of thyroid dysfunction was found in the PMS group.
  • Symptom relief in the L-T4 group (27% complete, 27% partial, 54% some relief) was not significantly different from the placebo group (45% complete, 23% partial, 68% some relief).
  • The previously reported high incidence of TH in PMS may be due to variations in the normal range for TSH levels in TRH stimulation tests.

Conclusions:

  • There is no significant association between thyroid disease and premenstrual syndrome (PMS).
  • Levothyroxine (L-T4) treatment is not more effective than placebo for alleviating PMS symptoms.
  • The interpretation of TRH stimulation tests may require re-evaluation for diagnosing thyroid issues in PMS patients.