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Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
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Published on: February 12, 2016

CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke

Xuefang Ren1, Kozaburo Akiyoshi, Arthur A Vandenbark

  • 1Neuroimmunology Research, R&D-31, Portland Veterans Affairs Medical Center, 3710 SW US Veterans Hospital Rd., Portland, OR 97239, USA.

Metabolic Brain Disease
|November 18, 2010
PubMed

Experimental cerebral ischemic stroke is exacerbated by inflammatory T-cells and is accompanied by systemic increases in CD4+CD25+Foxp3+ regulatory T-cells (Treg). To determine their effect on ischemic brain injury, Treg were depleted in Foxp3(DTR) mice prior to stroke induction. In contrast to a recent Nature Medicine report, our results demonstrate unequivocally that Treg depletion did not affect stroke infarct volume, thus failing to implicate this regulatory pathway in limiting stroke damage.

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