Related Experiment Video
Updated: Jun 6, 2026
Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
Published on: November 30, 2015
Performance properties of filter paper devices for whole blood collection
Joanne V Mei1, Sherri D Zobel, Elizabeth M Hall
1Centers for Disease Control and Prevention, 4770 Buford Highway NE, Chamblee, GA 30341, USA. jmei@cdc.gov
Background:
The Newborn Screening Quality Assurance Program at the Centers for Disease Control and Prevention assesses the adherence to established performance standards of manufactured lots of whole blood filter paper collection devices that are registered by the US FDA. We examined 26 newborn screening analytes measured from blood applied to filter papers from two FDA-cleared sources, Whatman(®) Grade 903 and Ahlstrom Grade 226. The dried blood spots contained analytes at both single levels and dose-response series.
Results:
We observed overlap at one standard deviation for each analyte, with no more than 4-5% difference between the papers.
Conclusion:
The data demonstrated similarities of analyte recovery between the papers, indicating comparability of the devices for newborn screening and other applications.
