Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genital chronic graft-versus-host disease: an unmet need that requires trained gynecologists.

Climacteric : the journal of the International Menopause Society·2024
Same author

Treating genitourinary syndrome of menopause in breast cancer survivors: main challenges and promising strategies.

Climacteric : the journal of the International Menopause Society·2023
Same author

Peer review? No thanks!

Climacteric : the journal of the International Menopause Society·2022
Same author

Safety of prasterone in breast cancer survivors treated with aromatase inhibitors: the VIBRA pilot study.

Climacteric : the journal of the International Menopause Society·2022
Same author

Pre-induction cervical ripening with different initial doses of intravaginal misoprostol: time to delivery and peri-natal outcomes.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·2022
Same author

Weight gain in menopause: systematic review of adverse events in women treated with black cohosh.

Climacteric : the journal of the International Menopause Society·2021

Related Experiment Video

Updated: Jun 6, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Isoflavones: effects on bone health.

C Castelo-Branco1, M J Cancelo Hidalgo

  • 1Institut Clinic of Gynecology, Obstetrics and Neonatology, Faculty of Medicine, University of Barcelona, and Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Climacteric : the Journal of the International Menopause Society
|November 19, 2010
PubMed
Summary

Isoflavones show potential benefits for bone health, particularly in menopausal women. Further research is needed to confirm their role in preventing bone loss and fractures.

More Related Videos

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice
07:20

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

Related Experiment Videos

Last Updated: Jun 6, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice
07:20

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

Area of Science:

  • Nutritional Biochemistry
  • Bone Physiology
  • Phytoestrogens

Background:

  • Isoflavones are plant compounds with hypothesized positive effects on bone health.
  • Existing research explores the relationship between isoflavones and various bone health indicators.

Purpose of the Study:

  • To systematically review the effects of isoflavones on bone remodeling markers, bone density, bone quality, and fracture incidence.
  • To synthesize evidence from in vitro, animal, and human studies.

Main Methods:

  • Systematic literature review of in vitro, animal, and human studies.
  • Electronic searches of MEDLINE and Cochrane Controlled Clinical Trials Register.
  • Hand-search of reference lists from selected review papers.

Main Results:

  • Isoflavones demonstrated potential to stimulate osteoblastic bone formation and inhibit osteoclastic bone resorption in preclinical studies.
  • Evidence suggests a beneficial effect of isoflavones on bone health in peri- and postmenopausal women consuming high-isoflavone soy protein.
  • Inconsistencies in results were attributed to study design, soy source, timing, and isoflavone bioavailability.

Conclusions:

  • Most studies indicate a positive association between isoflavones and bone health.
  • Further rigorous clinical trials are necessary to confirm efficacy and optimal usage for preventing bone loss and fractures.