Related Experiment Video
Updated: Jun 6, 2026
08:04
Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method
Published on: October 23, 2018
Ischemia modified albumin changes - review and clinical implications
Eftihia Sbarouni1, Panagiota Georgiadou, Vassilis Voudris
12nd Department of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece. esbarouni@yahoo.gr
Clinical Chemistry and Laboratory Medicine
|November 19, 2010
Summary
Ischemia modified albumin (IMA) shows promise for early ischemia detection. This biomarker may aid in diagnosing acute coronary syndromes (ACS) alongside traditional methods.
Area of Science:
- Cardiology
- Biochemistry
Background:
- Ischemia modified albumin (IMA) is a potential biomarker for detecting ischemia.
- Early detection of ischemia is crucial to prevent irreversible cardiac injury.
Purpose of the Study:
- To review available information on IMA, including its pathophysiology, analysis, clinical applications, and future perspectives.
- To assess the utility of IMA in the diagnostic window for acute coronary syndromes (ACS).
Main Methods:
- Literature search of MEDLINE using terms: IMA, biomarkers, and ischemia.
- Review of existing data on IMA's role in cardiac diagnostics.
Main Results:
- IMA is a promising biomarker for early ischemia detection before irreversible damage.
- IMA may complement electrocardiogram and cardiac troponins in diagnosing ACS in the Emergency Department.
Conclusions:
- IMA holds potential for early ischemia detection and ACS diagnosis.
- Further research is needed to establish IMA's prognostic significance in ACS and post-revascularization.
Related Concept Videos
01:24Nephrotic Syndrome I : Introduction
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
01:29Factors Affecting Protein-Drug Binding: Patient-Related Factors
Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
01:24Nephrotic Syndrome III : Nursing Management
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
01:26Nephrotic Syndrome II : Assessment and Medical Management
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
01:29Drug Distribution: Plasma Protein Binding
Drugs predominantly attach to plasma proteins, with only a small percentage remaining unbound. The unbound portion can be calculated as one minus the bound fraction. Acidic drugs form large, inactive complexes by reversibly binding to plasma albumin, which prevents them from diffusing across biological barriers. These drug-protein complexes act as reservoirs for the drugs. As the concentration of unbound drugs decreases, these complexes quickly dissociate to release the free drug, maintaining...