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Myeloid growth factors as anti-infective measures in children with leukemia and lymphoma

Thomas Lehrnbecher1, Ursula Creutzig

  • 1Pediatric Hematology and Oncology, Children's Hospital III, Johann Wolfgang Goethe-University, Theodor-Stern-Kai 7, Frankfurt, Germany. thomas.lehrnbecher@kgu.de

Expert Review of Hematology
|November 19, 2010
PubMed

Insights

Hematopoietic growth factors like G-CSF and GM-CSF reduced neutropenia in pediatric leukemia and lymphoma patients but did not lower infection risk or improve survival. Caution is advised due to potential relapse risks.

Area of Science:

  • Pediatric Hematology Oncology
  • Hematopoietic Stem Cell Support

Background:

  • Hematopoietic colony-stimulating factors (CSFs) are used in pediatric cancer treatment.
  • Granulocyte (G)-CSF and granulocyte-macrophage (GM)-CSF are commonly administered CSFs.

Purpose of the Study:

  • To evaluate the efficacy of G-CSF and GM-CSF in children with leukemia and lymphoma.
  • To assess the impact of CSFs on neutropenia, infectious complications, and survival.

Main Methods:

  • Analysis of clinical trial data in pediatric patients with leukemia and lymphoma.
  • Comparison of outcomes between patients receiving CSFs and those not.

Main Results:

  • G-CSF and GM-CSF reduced the duration and severity of neutropenia.
  • Neither G-CSF nor GM-CSF significantly decreased infectious complications or improved overall survival.
  • Antibiotic use and hospitalization rates appeared to decrease with CSF administration.

Conclusions:

  • While CSFs mitigate neutropenia in pediatric leukemia/lymphoma patients, they do not reduce infection risk or improve survival.
  • Guidelines recommend cautious use of hematopoietic growth factors in these populations due to potential relapse concerns.

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