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Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Related Experiment Video

Updated: Jun 6, 2026

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs
08:19

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs

Published on: July 12, 2022

Left ventricular function many years after recovery from pre-eclampsia.

I Strobl1, G Windbichler, A Strasak

  • 1Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria. isolde.strobl@i-med.ac.at

BJOG : an International Journal of Obstetrics and Gynaecology
|November 19, 2010
PubMed
Summary
This summary is machine-generated.

Women with a history of pre-eclampsia or HELLP syndrome show impaired cardiac function years later. This study highlights increased cardiovascular disease risk in these women, emphasizing the need for long-term monitoring.

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Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs
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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

Published on: April 17, 2021

Area of Science:

  • Cardiology
  • Obstetrics
  • Epidemiology

Background:

  • Women with pre-eclampsia face higher risks of future cardiovascular disease.
  • HELLP syndrome (hemolysis, elevated liver enzymes, low platelets) is a severe pregnancy complication.
  • Long-term cardiovascular effects of pre-eclampsia and HELLP syndrome require further investigation.

Purpose of the Study:

  • To assess maternal hemodynamics in asymptomatic women years after experiencing pre-eclampsia or HELLP syndrome.
  • To evaluate cardiac function in women with a history of these pregnancy complications compared to controls.

Main Methods:

  • A case-control study involving 48 women, 13-18 years post-pregnancy.
  • Participants included women with a history of HELLP syndrome (17), pre-eclampsia (14), and normal pregnancies (17).
  • Echocardiography was used to measure cardiac function parameters like MPI, ICT+IVRT, and ejection time.

Main Results:

  • Women with prior HELLP syndrome exhibited significantly increased myocardial performance index (MPI) and isovolumetric contraction/relaxation times (ICT+IVRT).
  • Women with a history of pre-eclampsia showed a significantly increased MPI and decreased ejection time (ET).
  • No significant differences in transmitral early to atrial filling velocity ratio (MV-E/A), stroke volume (SV), or cardiac output (CO) were observed between groups.

Conclusions:

  • This study supports epidemiological findings linking pre-eclampsia to increased cardiovascular disease risk.
  • Asymptomatic women with a history of HELLP syndrome or pre-eclampsia demonstrate impaired cardiac function years later, indicated by elevated MPI.
  • Findings underscore the importance of long-term cardiovascular monitoring for women with a history of these pregnancy complications.