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Published on: June 10, 2021
Population pharmacokinetic analysis of the active product of dipyrone
1Division of Clinical Pharmacology, Hadassah University Hospital, Jerusalem, Israel.
Objective:
Pharmacokinetics of 4-methyl-amino-antipyrine (MAA), the active metabolite of the nonsteroidal anti-inflammatory agent dipyrone, whose time course correlates to the therapeutic effect of the drug, are studied.
Study Design And Setting:
153 patients hospitalized in the Department of Medicine at the Hadassah University Hospital, Jerusalem, Israel.
Intervention:
Patients receiving dipyrone for the treatment of fever or pain were asked to participate in the study. Pharmacokinetics and statistical analysis: Using the population approach based on a formerly developed experimental model, the relationships between pharmacokinetic parameters and demographic and physiological covariates are explored.
Results:
The results of the analysis show considerable variability in pharmacokinetics across the study population, and a significant decrease in clearance with age.
Conclusion:
A population pharmacokinetic analysis of MAA, the active product of dipyrone, reveals that age is a significant predictor of MAA disposition. Covariates that measure hepatic and renal function do not appear to be good predictors of the rate of MAA disposition.
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