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Related Concept Videos

Yellow Fever01:18

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
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Cross-reactivity

Overview
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...

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Related Experiment Video

Updated: Jun 6, 2026

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes
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Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes

Published on: September 27, 2014

Ebola haemorrhagic fever.

Heinz Feldmann1, Thomas W Geisbert

  • 1Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA. feldmannh@niaid.nih.gov

Lancet (London, England)
|November 19, 2010
PubMed
Summary

Ebola virus causes severe hemorrhagic fever in Africa with up to 90% fatality. This deadly virus impacts public health, wildlife, and poses bioterrorism risks, with no available treatments.

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Area of Science:

  • Virology
  • Public Health
  • Epidemiology

Background:

  • Ebola virus causes severe hemorrhagic fever in humans, endemic to Central Africa.
  • Reston Ebola virus, found in the Philippines, has not been linked to human disease.
  • Ebola poses a significant public health threat in Africa and globally due to imported cases and bioterrorism concerns.

Purpose of the Study:

  • To summarize the epidemiology and clinical characteristics of Ebola virus infections.
  • To highlight the public health impact and lack of treatment options for Ebola virus disease.

Main Methods:

  • Literature review of Ebola virus research.
  • Analysis of epidemiological data and case studies.

Main Results:

  • Ebola virus infections are characterized by immune suppression and systemic inflammation.
  • The disease leads to multi-organ failure and shock, similar to septic shock.
  • African Ebola species have case-fatality rates as high as 90%.

Conclusions:

  • Ebola virus remains a critical threat in Africa, impacting human and great ape populations.
  • Urgent need for prophylaxis and treatment development for Ebola virus disease.
  • Understanding Ebola's pathology is crucial for managing outbreaks and potential bioterrorism threats.