Related Experiment Video
Updated: Jun 6, 2026

Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes
Published on: March 2, 2020
Synthesis and antibacterial activity of novel 4-aryl-[1,2,3]-triazole containing macrolides
David Pereira1, Prabhavathi Fernandes
1Cempra Pharmaceuticals, Inc, Building Four Quadrangle, 6340 Quadrangle Drive, Suite 100, Chapel Hill, NC 27517, United States. dpereira@cempra.com
Abstract:
Two series of novel triazole containing 14-member macrolides having either a cladinose or a 3-pyridyl acetate group at the 3-position of the macrolide ring were synthesized. The in vitro antibacterial activities against S. aureus, S. pneumoniae, S. pyogenes and E. faecalis were determined. Macrolide 7a and the fluoroketolide 1 (CEM-101) were evaluated in vivo in murine systemic infection models. All of the macrolide analogs were less active in vitro and in vivo than the fluoroketolide 1 (CEM-101).
Related Concept Videos
Inhibitors of Bacterial Protein Synthesis
Inhibitors of Bacterial DNA Synthesis
Inhibitors of Gram-positive Cell Wall Synthesis
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Mechanism of Antibiotic Resistance in MRSA
![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)