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Pore diameter mapping using double pulsed-field gradient MRI and its validation using a novel glass capillary array

Michal E Komlosh¹, Evren Özarslan, Martin J Lizak

¹Section on Tissue Biophysics and Biomimetics, Program on Pediatric Imaging and Tissue Sciences, NICHD, NIH, Bethesda, MD 20892-5772, USA. komloshm@mail.nih.gov

Journal of Magnetic Resonance (San Diego, Calif. : 1997)

|November 19, 2010

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This study introduces a new MRI phantom using glass capillary arrays (GCA) to accurately measure local pore diameter. The validated double pulsed-field gradient (d-PFG) MRI method precisely maps pore sizes in porous materials.

Area of Science:

Magnetic Resonance Imaging
Materials Science
Biophysics

Background:

Double pulsed-field gradient (d-PFG) MRI offers quantitative microstructural insights in porous media and tissues.
Accurate calibration and validation of d-PFG MRI methods are crucial for reliable microstructural mapping.

Purpose of the Study:

To develop and validate a novel MRI phantom for calibrating d-PFG MRI.
To accurately measure and map local pore diameters in porous materials using d-PFG MRI.

Main Methods:

Utilized highly ordered glass capillary arrays (GCA) as a novel MRI phantom.
Employed d-PFG Spin-Echo Filtered MRI with a new theoretical framework.
Accounted for all diffusion and imaging gradients, including violations of the short gradient pulse approximation.

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Main Results:

Diameter maps generated by d-PFG MRI showed excellent agreement with optical microscopy and single PFG diffusion diffraction NMR spectroscopy.
Pixel-by-pixel analysis confirmed precise and accurate mapping of local pore diameters.
The novel GCA phantom proved effective for validating d-PFG MRI pore size measurements.

Conclusions:

The proposed GCA phantom and d-PFG MRI method enable accurate, quantitative mapping of local pore diameters.
This approach advances the capability of MRI for characterizing microstructural features in porous materials.
The validated method holds promise for applications in materials science and biomedical imaging.