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Updated: Jun 6, 2026
10:04
Enhancing Tumor Content through Tumor Macrodissection
Published on: February 12, 2022
[Molecular abnormalities in lymphomas]
1Université Paul-Sabatier,CHU de Toulouse-Purpan, Toulouse, France. georges.delsol@inserm.fr
Bulletin Du Cancer
|November 19, 2010
Summary
Molecular abnormalities like mutations and translocations are key in diagnosing and classifying lymphomas. Understanding these genetic changes aids in developing targeted therapies for various lymphoma types.
Area of Science:
- Hematology
- Oncology
- Molecular Biology
Context:
- Lymphomas exhibit diverse molecular abnormalities crucial for diagnosis, prognosis, and classification.
- These abnormalities include gene mutations, translocations, amplifications, and deletions, impacting tumor suppressor genes.
- Techniques like cytogenetics, FISH, CGH array, and gene expression profiling detect these anomalies.
Purpose:
- To review molecular abnormalities in common B, T, and NK cell lymphomas.
- To highlight diagnostic and prognostic implications of these genetic alterations.
- To discuss the role of molecular profiling in understanding lymphoma pathogenesis.
Summary:
- Diffuse large B-cell lymphomas show distinct gene expression profiles (GCB vs. ABC).
- Specific molecular alterations identified in follicular, MALT, mantle cell, and Burkitt lymphomas (e.g., BCL2, API2-MALT1, CCND1, c-Myc).
- T and NK cell lymphomas, except ALK-positive anaplastic large cell lymphoma, have less recurrent molecular anomalies, though gene deregulation is noted.
Impact:
- Molecular insights guide lymphoma classification (WHO) and therapeutic strategies.
- Identification of ALK fusion protein in ALK-positive anaplastic large cell lymphoma offers a target for specific inhibitors.
- Understanding infectious agent roles (EBV, HTLV1, H. pylori) in lymphomagenesis informs prevention and treatment.
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