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Partial cross-dependence on ethanol in mice dependent on chlordiazepoxide
A W Chan1, M C Langan, F W Leong
1Research Institute on Alcoholism, New York State Division of Alcoholism and Alcohol Abuse, Buffalo 14203.
Pharmacology, Biochemistry, and Behavior
|February 1, 1990
Summary
Chlordiazepoxide (CDP) withdrawal in mice caused withdrawal signs, which ethanol partially suppressed. However, ethanol did not prevent appetite loss or weight reduction, indicating partial cross-dependence.
Area of Science:
- Neuroscience
- Pharmacology
- Behavioral Science
Background:
- Chronic chlordiazepoxide (CDP) administration leads to physical dependence.
- Benzodiazepine receptor antagonists, like Ro15-1788, can precipitate withdrawal symptoms.
Purpose of the Study:
- To investigate the cross-dependence between chlordiazepoxide (CDP) and ethanol.
- To assess the efficacy of ethanol in mitigating CDP withdrawal symptoms and associated physiological changes.
Main Methods:
- Mice were chronically fed a liquid diet containing chlordiazepoxide (CDP).
- Withdrawal signs were induced by CDP withdrawal and administration of Ro15-1788.
- Ethanol was administered via injection or diet to assess its effects on withdrawal.
Main Results:
- Ethanol injection significantly suppressed Ro15-1788-induced CDP withdrawal signs.
- Ethanol did not prevent appetite loss or weight loss during CDP withdrawal.
- CDP-dependent mice exhibited more severe hypothermia during ethanol withdrawal and retained increased activity.
Conclusions:
- Chlordiazepoxide (CDP)-dependent mice show partial cross-dependence on ethanol.
- Ethanol can attenuate some, but not all, aspects of CDP withdrawal.
- Further research is needed to understand the complex interactions between benzodiazepines and ethanol.