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Related Experiment Videos

Interaction between antidepressants and d-amphetamine on variable-interval performance.

K Shah1, C M Bradshaw, E Szabadi

  • 1Department of Psychiatry, University of Manchester, UK.

Psychopharmacology
|January 1, 1990
PubMed
Summary

Certain antidepressants, like imipramine and fluvoxamine, amplify the suppressive effects of d-amphetamine on rat operant behavior. This interaction suggests a role for serotonin in d-amphetamine

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Behavioral Science

Background:

  • Antidepressant drugs modulate neurotransmitter systems.
  • d-Amphetamine affects operant behavior and neurotransmitter release.
  • Interactions between antidepressants and stimulants are not fully understood.

Purpose of the Study:

  • To investigate the interaction between antidepressants (imipramine, desipramine, fluvoxamine, trazodone) and d-amphetamine on operant behavior in rats.
  • To explore the potential mechanisms underlying these interactions, including neurotransmitter uptake inhibition.

Main Methods:

  • Four experiments were conducted using 12 rats each.
  • Operant behavior was maintained under a variable-interval 80-s schedule of sucrose reinforcement.
  • Drugs were administered alone or in combination, and response rates were measured.

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Main Results:

  • d-Amphetamine dose-dependently suppressed response rates.
  • Imipramine and desipramine had no effect alone; fluvoxamine and trazodone increased response rates.
  • Imipramine, desipramine, and fluvoxamine potentiated d-amphetamine's suppressant effect, while trazodone did not.

Conclusions:

  • Imipramine, desipramine, and fluvoxamine may enhance d-amphetamine's ability to reduce response capacity.
  • The potentiation by fluvoxamine suggests a role for 5-hydroxytryptamine (5HT) in d-amphetamine's effects.
  • Trazodone's lack of effect might be due to its minimal influence on uptake mechanisms.