Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
Real Time RT-PCR02:57

Real Time RT-PCR

Real-time reverse transcription-polymerase chain reaction, or Real-time RT-PCR, is an analytical tool used to determine the expression level of target genes. The method involves converting mRNA to complementary DNA with the help of an enzyme known as reverse transcriptase, followed by the PCR amplification of the cDNA. These two processes can be performed simultaneously in a single tube or separately as a two-step reaction.
The real-time quantification of the number of amplified products is...
Genetic Variation01:25

Genetic Variation

Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles, which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: A differential process mining analysis of COVID-19 management for cancer patients.

Frontiers in oncology·2026
Same author

Single nucleotide variants in <i>UNC13C</i> associated with neurodevelopmental disorders affect ethanol sensitivity in <i>Drosophila</i>.

Biochemistry and biophysics reports·2025
Same author

Genetic modifiers and ascertainment drive variable expressivity of complex disorders.

Cell·2025
Same author

Bi-allelic variants in BRF2 are associated with perinatal death and craniofacial anomalies.

Genome medicine·2025
Same author

Development and validation of an epigenetic signature of allostatic load.

Bioscience reports·2025
Same author

Further delineation of the SCAF4-associated neurodevelopmental disorder.

European journal of human genetics : EJHG·2024
Same journal

Complete sequencing of medaka genomes reveals the architecture of centromeric satellites, giant mobile elements, and sex chromosomes.

Genome research·2026
Same journal

Convergence and conflict among telomere specialized transposons across 60 million years of Drosophilid evolution.

Genome research·2026
Same journal

A unified analysis of cell type- and trajectory-associated pathways in single-cell data using Phoenix.

Genome research·2026
Same journal

Resf1 is required for proper placental development and configuration of trophoblast cell-specific heterochromatin.

Genome research·2026
Same journal

Telomere-driven replicative crisis is driven by large-scale changes in genomic architecture.

Genome research·2026
Same journal

Spatially informed reference-free cell-type deconvolution for spatial transcriptomics with SpatialCD.

Genome research·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
09:30

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

Copy number variation modifies expression time courses.

Evelyne Chaignat1, Emilie Aït Yahya-Graison, Charlotte N Henrichsen

  • 1Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland.

Genome Research
|November 19, 2010
PubMed
Summary
This summary is machine-generated.

DNA segment copy number variation (CNV) influences gene expression throughout mouse development. CNVs can alter gene expression levels and timing, impacting gene regulation across different life stages and strains.

More Related Videos

Detection of Copy Number Alterations Using Single Cell Sequencing
09:45

Detection of Copy Number Alterations Using Single Cell Sequencing

Published on: February 17, 2017

Measuring mRNA Levels Over Time During the Yeast S. cerevisiae Hypoxic Response
09:45

Measuring mRNA Levels Over Time During the Yeast S. cerevisiae Hypoxic Response

Published on: August 10, 2017

Related Experiment Videos

Last Updated: Jun 6, 2026

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
09:30

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

Detection of Copy Number Alterations Using Single Cell Sequencing
09:45

Detection of Copy Number Alterations Using Single Cell Sequencing

Published on: February 17, 2017

Measuring mRNA Levels Over Time During the Yeast S. cerevisiae Hypoxic Response
09:45

Measuring mRNA Levels Over Time During the Yeast S. cerevisiae Hypoxic Response

Published on: August 10, 2017

Area of Science:

  • Genetics
  • Developmental Biology
  • Genomics

Background:

  • Copy number variations (CNVs) are DNA rearrangements influencing gene expression.
  • CNVs can affect genes within, flanking, and distant from the variation.
  • Understanding CNV effects across development is crucial.

Purpose of the Study:

  • To investigate the impact of CNVs on gene expression throughout mouse development.
  • To determine if spatial expression patterns of CNV genes are maintained during development.
  • To explore developmental modulation of CNV gene expression and strain-specific expression timing.

Main Methods:

  • Monitoring gene expression effects of CNVs across multiple life stages in mice.
  • Analyzing spatial expression patterns of genes within CNVs.
  • Comparing temporal expression profiles of CNV genes between different mouse strains.

Main Results:

  • CNV-mediated gene expression controls are effective throughout mouse development.
  • Spatial expression patterns of CNV genes are generally maintained throughout life.
  • Some brain-expressed genes within CNVs show temporally modulated compensatory loops during development.
  • CNV genes are enriched in transcripts with variable expression time courses between strains.

Conclusions:

  • CNVs significantly influence gene expression levels and patterns during development.
  • The timing of gene expression can be altered by CNVs, in addition to expression levels.
  • CNVs play a role in developmental gene regulation and inter-strain variability.