Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 6, 2026

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

Evaluation of novel stimulus waveforms for deep brain stimulation.

Thomas J Foutz1, Cameron C McIntyre

  • 1Cleveland Clinic Foundation, Department of Biomedical Engineering, 9500 Euclid Ave. ND20, Cleveland, OH 44195, USA.

Journal of Neural Engineering
|November 19, 2010
PubMed
Summary

New deep brain stimulation (DBS) waveforms may significantly reduce energy use. A centered-triangular pulse shows potential for substantial energy savings compared to traditional rectangular pulses in neurological treatments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Localizing beta synchronous neurons in the STN using directional DBS recordings and patient-specific biophysical models.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same author

Model-based design of subthalamic nucleus neurons using hybrid optimization.

Journal of neurophysiology·2026
Same author

Bidirectional sleep-seizure interactions and orexin in a mouse model of tuberous sclerosis complex-related epilepsy.

Epilepsia·2026
Same author

Breaking Bad Networks: Dorsal Striatal Stimulation for Seizure Control.

Epilepsy currents·2025
Same author

Comprehensive map of axonal pathway activation as a function of subthalamic deep brain stimulation location and parameter settings.

Brain stimulation·2025
Same author

Evaluation of DBS computational modeling methodologies using in-vivo electrophysiology in Parkinson's disease.

Brain stimulation·2025

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Computational Modeling

Background:

  • Deep brain stimulation (DBS) is a standard therapy for neurological disorders.
  • Current DBS systems primarily use rectangular stimulation waveforms.
  • Emerging research suggests non-rectangular waveforms could offer advantages.

Purpose of the Study:

  • To compare the neural activation energy of various charge-balanced biphasic waveforms against traditional rectangular pulses.
  • To evaluate these waveforms under intracellular and extracellular stimulation conditions.
  • To assess the impact of waveform delivery via a clinical DBS electrode versus a point source.

Main Methods:

  • Utilized detailed computer models to simulate neural activation.
  • Compared rectangular, exponential, triangular, Gaussian, and sinusoidal pulse shapes.

More Related Videos

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Related Experiment Videos

Last Updated: Jun 6, 2026

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

  • Analyzed energy consumption for stimulating axonal fibers and projection neurons.
  • Modeled stimulation through a clinical DBS electrode.

    • Main Results:

    • A 1 ms centered-triangular pulse reduced energy consumption by 64% compared to a standard 100 µs rectangular pulse (48 nJ vs. 133 nJ for 50% axon stimulation).
    • The triangular pulse offered a 10% energy saving over the most efficient rectangular pulse (1.25 ms duration).
    • Non-rectangular waveforms showed potential for energy efficiency in extracellular stimulation.

    Conclusions:

    • Optimized non-rectangular waveforms, such as the centered-triangular pulse, can significantly reduce energy consumption in deep brain stimulation.
    • These findings suggest potential for measurable energy savings in clinical DBS applications.
    • Further experimental investigation is warranted to validate these computational findings.