Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...

Acute Kidney Injury I: Introduction

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...

Acute Kidney Injury II: Pathophysiology

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Exploring Student Experiences in a Transdisciplinary Clinical Immersion Course on Needs Identification in Veteran and Service Member Healthcare Settings.

Biomedical engineering education·2026

Same author

Homelessness and Risk of End-Stage Kidney Disease and Death in Veterans With Chronic Kidney Disease.

JAMA network open·2024

Same author

Role of Anemia in Dementia Risk Among Veterans With Incident CKD.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2023

Same author

Analysis of urine Raman spectra differences from patients with diabetes mellitus and renal pathologies.

PeerJ·2023

Same author

Age-Related Association between Multimorbidity and Mortality in US Veterans with Incident Chronic Kidney Disease.

American journal of nephrology·2022

Same author

Discovery of Novel Proteomic Biomarkers for the Prediction of Kidney Recovery from Dialysis-Dependent AKI Patients.

Kidney360·2021

Search research articles

Related Experiment Video

Updated: Jun 6, 2026

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

Acute kidney injury: current perspectives.

Devasmita Choudhury¹

¹VA North Texas Health Care Systems, Dallas VA Medical Center, Dallas, TX 75216, USA. devasmita.dev@va.gov

Postgraduate Medicine

|November 19, 2010

Summary

This summary is machine-generated.

Acute kidney injury (AKI) poses significant risks, especially for critically ill patients. Current research focuses on early biomarkers and novel therapies like bioartificial dialyzers and stem cell regeneration to improve AKI management.

More Related Videos

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

Related Experiment Videos

Last Updated: Jun 6, 2026

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

Area of Science:

Nephrology
Critical Care Medicine

Background:

Acute kidney injury (AKI) is a major contributor to morbidity and mortality, particularly in critically ill patients.
Standardized definitions (RIFLE, AKIN) and improved understanding of AKI pathobiology aid in early injury detection.
Despite progress, therapeutic challenges remain in AKI management, including prophylaxis and renal replacement therapy.

Purpose of the Study:

To review current practices and available therapies for acute kidney injury.
To highlight ongoing research and potential future treatments for AKI.

Main Methods:

Literature review of recent advancements in AKI definitions, pathobiology, and therapeutic strategies.
Analysis of current clinical challenges and emerging treatment modalities.

Main Results:

Standardized AKI criteria facilitate early identification of kidney injury.
Ongoing research explores novel biomarkers for early detection and intervention.
Investigational therapies include bioartificial dialyzers, plasma therapies, and stem cell regeneration.

Conclusions:

Early identification and intervention are crucial for managing acute kidney injury.
Future AKI treatment may involve advanced technologies and regenerative medicine approaches.
Continued research is vital to address therapeutic challenges and improve patient outcomes in AKI.