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Related Concept Videos

Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
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Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
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Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

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Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
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Related Experiment Video

Updated: Jun 6, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Dapoxetine for premature ejaculation.

A M Feige1, M R Pinsky, W J G Hellstrom

  • 1Department of Urology, Tulane Health Sciences Center, New Orleans, Louisiana, USA.

Clinical Pharmacology and Therapeutics
|November 19, 2010
PubMed
Summary
This summary is machine-generated.

Premature ejaculation (PE), a common male sexual dysfunction affecting 20-30% globally, significantly impacts quality of life. Lack of ejaculatory control is a key diagnostic feature across definitions.

Related Experiment Videos

Last Updated: Jun 6, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Area of Science:

  • Urology
  • Sexual Medicine
  • Psychiatry

Background:

  • Premature ejaculation (PE) is the most prevalent male sexual dysfunction.
  • It significantly affects men's quality of life and interpersonal relationships.
  • Estimated global prevalence ranges from 20% to 30%.

Purpose of the Study:

  • To define and characterize premature ejaculation (PE).
  • To highlight the impact of PE on individuals and relationships.
  • To discuss diagnostic criteria and predictors of PE.

Main Methods:

  • Review of diagnostic criteria from DSM-IV-TR and the International Society of Sexual Medicine.
  • Analysis of clinical definitions and their common elements.
  • Identification of ejaculatory control as a key predictor.

Main Results:

  • PE is defined by persistent/recurrent ejaculation with minimal stimulation, causing distress.
  • Diagnostic criteria include ejaculatory latency (e.g., <1 minute) and lack of control.
  • Lack of ejaculatory control is a consistent and sensitive predictor.

Conclusions:

  • Premature ejaculation is a widespread condition with significant psychosocial consequences.
  • Consistent diagnostic features include lack of ejaculatory control and distress.
  • Understanding these definitions is crucial for diagnosis and treatment.