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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Effect of antihypertensive therapy on cognitive functions of patients with hypertension

Ashok Jaiswal1, V Bhavsar, Jaykaran

  • 1Marketing, Zydus Cedilla, Ahmedabad India.

Annals of Indian Academy of Neurology
|November 19, 2010
PubMed

Insights

Antihypertensive therapy improved cognitive function in newly diagnosed hypertensive patients. Three months of treatment led to increased scores in most cognitive tests, with no observed decline.

Area of Science:

  • Neurology
  • Cardiology
  • Gerontology

Background:

  • Hypertension is a known risk factor for cognitive decline.
  • Antihypertensive therapy is often prescribed to manage hypertension and potentially mitigate cognitive impairment.
  • Existing research presents conflicting evidence regarding the protective effects of antihypertensive drugs on cognitive function.

Purpose of the Study:

  • To evaluate the cognitive status of patients recently diagnosed with hypertension.
  • To assess the impact of a 3-month antihypertensive therapy regimen on cognitive functions in these patients.

Main Methods:

  • Cognitive function was assessed using the PGI memory scale (PGIMS).
  • Baseline cognitive scores of hypertensive patients were compared to healthy volunteers.
  • Cognitive functions were re-evaluated after 3 months of antihypertensive treatment.
  • Statistical analysis included unpaired t-tests for between-group comparisons and paired t-tests for pre- and post-treatment assessments.

Main Results:

  • Hypertensive patients demonstrated lower mean scores across six cognitive subtests compared to the control group.
  • Following 3 months of antihypertensive therapy, significant improvements were observed in five cognitive subtests.
  • Four of the improved subtests corresponded to those initially showing deficits at baseline.

Conclusions:

  • Three months of antihypertensive therapy positively impacted cognitive function scores in hypertensive patients, particularly in areas of initial impairment.
  • The study found no evidence of cognitive deterioration after the 3-month treatment period.
Abstract

Keywords:
Antihypertensive therapycognitive functionshypertension

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