Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbial Phylogeny01:28

Microbial Phylogeny

Understanding the evolutionary relationships among microorganisms is fundamental to microbial ecology and taxonomy. Phylogenetic trees are essential tools for inferring these relationships, relying primarily on comparative analyses of molecular sequences such as DNA, RNA, or proteins. In microbial studies, these trees typically depict the evolutionary paths of diverse bacterial and archaeal species by mapping genetic differences accumulated over time.Phylogenetic trees are composed of tips,...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
The Tree of Life - Bacteria, Archaea, Eukaryotes02:40

The Tree of Life - Bacteria, Archaea, Eukaryotes

The “tree of life” describes the evolution of life and the evolutionary relationships between organisms. The root of the tree is the common ancestor to all life on Earth. All other species radiate from this point, much like the branches of a tree. The numerous tips of these branches on the tree of life represent every living, or extant, species. Extinct species, which are species that no longer exist, can be found towards the center of the tree. Currently, these organisms, both extant and...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Phylogeny01:23

Phylogeny

Phylogeny is concerned with the evolutionary diversification of organisms or groups of organisms. A group of organisms with a name is called a taxon (singular). Taxa (plural) can span different levels of the evolutionary hierarchy. For instance, the group containing all birds is a taxon (comprising the class Aves), and the group of all species of daisies (the genus Bellis) is a taxon. Phylogenies can likewise include just one genus (i.e., depict species relationships) or span an entire...
Protein Families02:47

Protein Families

Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key locations, protein...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: The geology and evolution of the Near-Earth binary asteroid system (65803) Didymos.

Nature communications·2024
Same author

The geology and evolution of the Near-Earth binary asteroid system (65803) Didymos.

Nature communications·2024
Same author

The Comet Interceptor Mission.

Space science reviews·2024
Same author

Momentum transfer from the DART mission kinetic impact on asteroid Dimorphos.

Nature·2023
Same author

Metabolomics for the future of personalized medicine through information and communication technologies.

Personalized medicine·2018
Same author

Two independent and primitive envelopes of the bilobate nucleus of comet 67P.

Nature·2015
Same journal

Organ-specific and time-dependent oxidative damage induced by chronic copper exposure: modulation by vitamin E.

Metallomics : integrated biometal science·2026
Same journal

The Cancer Metallome Continuum: A Framework for Understanding Metal Dysregulation from Carcinogenesis to Therapeutic Resistance.

Metallomics : integrated biometal science·2026
Same journal

Smart Cyclometalated Iridium Photosensitizers: Stimuli-Responsive and Theranostic Systems for Precision Phototherapy.

Metallomics : integrated biometal science·2026
Same journal

Phosphate availability modulates elemental homeostasis in rainbow trout hepatocytes: compositional ionomics illuminates system-wide adjustments.

Metallomics : integrated biometal science·2026
Same journal

Copper restriction unmasks axonal degeneration in a mouse model of X-linked hereditary motor neuropathy.

Metallomics : integrated biometal science·2026
Same journal

Genomic mapping reveals cisplatin disruption of protein phosphorylation signalling genome-wide.

Metallomics : integrated biometal science·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

Copper proteomes, phylogenetics and evolution.

Leonardo Decaria1, Ivano Bertini, Robert J P Williams

  • 1Magnetic Resonance Center (CERM) - University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy.

Metallomics : Integrated Biometal Science
|November 19, 2010
PubMed
Summary
This summary is machine-generated.

Organisms evolve by adapting their use of elements like copper in response to environmental changes. This study reveals how copper proteins diversified, especially in extracellular roles, mirroring increased environmental copper availability.

More Related Videos

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

Standards for Quantitative Metalloproteomic Analysis Using Size Exclusion ICP-MS
09:51

Standards for Quantitative Metalloproteomic Analysis Using Size Exclusion ICP-MS

Published on: April 13, 2016

Related Experiment Videos

Last Updated: Jun 6, 2026

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

Standards for Quantitative Metalloproteomic Analysis Using Size Exclusion ICP-MS
09:51

Standards for Quantitative Metalloproteomic Analysis Using Size Exclusion ICP-MS

Published on: April 13, 2016

Area of Science:

  • Biochemistry
  • Evolutionary Biology
  • Bioinorganic Chemistry

Background:

  • Environmental changes drive the evolution of elemental usage in organisms.
  • Previous work established a link between environmental shifts and organismal element utilization.
  • This study focuses on copper proteins under increasingly oxidizing environmental conditions.

Purpose of the Study:

  • To analyze the types and numbers of copper protein domains across diverse organisms.
  • To investigate the evolutionary trajectory of copper protein usage in response to environmental oxidation.
  • To compare copper protein evolution with that of iron and zinc proteins.

Main Methods:

  • Bioinformatic analysis of 435 DNA sequences from NCBI.
  • Utilized a developed method for identifying and quantifying copper domains.
  • Comparative analysis of copper, iron, and zinc protein families.

Main Results:

  • Copper domains are predominantly found in copper chaperones, homeostatic proteins, and extracellular redox enzymes.
  • A significant multiplicity of these copper-containing proteins was observed.
  • Evolution shows coordinated elemental chemistry development with increased protein copies as environmental availability rises.

Conclusions:

  • Evolutionary adaptation involves coordinated development of elemental chemistry and protein diversification.
  • Increased environmental availability of elements drives the expansion of related protein families.
  • Copper protein evolution, particularly extracellular, is linked to environmental oxidation and availability.