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06:08
Formulating and Characterizing an Exosome-based Dopamine Carrier System
Published on: April 4, 2022
Development and evaluation of vesicular system for curcumin delivery.
Nishant Kumar Gupta1, V K Dixit
1Department of Pharmaceutical Sciences, Dr. H. S. Gour Vishwavidyalaya, Sagar (MP), India. nishantsemail@gmail.com
Archives of Dermatological Research
|November 19, 2010
Summary
Phyto-vesicles effectively deliver curcumin topically, significantly boosting antioxidant and anti-aging effects. This novel vesicular system enhances curcumin
Area of Science:
- Cosmetic Science
- Dermatology
- Materials Science
Background:
- Topical curcumin formulations often fail to deliver significant antioxidant and anti-aging benefits.
- High curcumin concentrations in creams and gels show limited efficacy.
- Enhanced topical bioavailability is needed for effective curcumin delivery.
Purpose of the Study:
- To develop a vesicular system for improved topical curcumin delivery.
- To enhance curcumin's bioavailability and anti-aging properties.
- To compare the efficacy of novel curcumin formulations against plain curcumin.
Main Methods:
- Curcumin-phosphatidyl choline (PC) complex formation and characterization (TLC, DSC, melting point, IR).
- Preparation of phyto-vesicles, liposomes, and niosomes containing the curcumin complex.
- Incorporation of vesicular formulations into carbopol gel for topical application.
- Evaluation of anti-aging effects in UV-induced oxidative stress in mice.
Main Results:
- Successful formation of the curcumin-PC complex was confirmed by analytical and spectroscopic data.
- Phyto-vesicles demonstrated superior antioxidant and anti-aging effects compared to other formulations and plain curcumin.
- The enhanced efficacy is attributed to the amphiphilic nature of the complex, improving curcumin's miscibility.
Conclusions:
- Curcumin-PC complex and its derived phyto-vesicles offer superior anti-aging and antioxidant properties.
- Phyto-vesicles represent a highly effective delivery system for topical curcumin.
- This approach significantly enhances anti-wrinkle and antioxidant effects for skincare applications.
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