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Updated: Jun 6, 2026

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Published on: May 6, 2018
An unusual case of anti-glomerular basement membrane disease presenting with nephrotic syndrome
Chidi C Okafor1, Rasheed A Balogun, David T Bourne
1Division of Nephrology, Department of Medicine, University of Virginia, Box 800133, Charlottesville, VA 22908, USA.
Abstract:
Anti-glomerular basement membrane (anti-GBM) disease is a vasculitic disease characterized by acute kidney injury, oliguria, hematuria and proteinuria. Proteinuria is rarely in the nephrotic range. A case of anti-GBM disease with proteinuria of 22.5 g/day is discussed. Immunofluorescence showed strong linear IgG deposits while electron microscopy showed widespread visceral epithelial cell foot cell process effacement. No electron dense immune complex-type deposits were identified. Pathology findings were not suggestive of simultaneous presentation of anti-GBM disease and other diseases associated with nephrotic range proteinuria. Anti-GBM disease should be considered in a comprehensive differential diagnosis of severe proteinuria.
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