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Updated: Jun 6, 2026
09:07
Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
Published on: June 10, 2018
Redefining the concept of standardization for pluripotent stem cells
Shintaro Sengoku1, Koichi Sumikura, Toshihiko Oki
1The Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Yoshida-Ushinomiyacho, Sakyo-ku, Kyoto, 606-8501, Japan. ssengoku@icems.kyoto-u.ac.jp
Stem Cell Reviews and Reports
|November 19, 2010
Summary
This study proposes a comprehensive framework for managing pluripotent stem cell technologies, addressing limitations in current standardization efforts to foster broader clinical applications and research development.
Area of Science:
- Biotechnology
- Stem Cell Research
- Technology Management
Background:
- Current standardization initiatives for pluripotent stem cells are limited in scope.
- Existing frameworks often overlook the full spectrum of stem cell types and technological opportunities for clinical application.
Purpose of the Study:
- To propose an exhaustive and strategic framework for the standardization and management of pluripotent stem cell technologies.
- To address the narrow scope of current standardization practices and promote wider applicability.
Main Methods:
- Review of global and regional initiatives for technology standardization in pluripotent stem cells.
- Observational analysis of standardization attempts in the UK, US, and Japan.
- Development of a strategic framework emphasizing comprehensiveness and management science principles.
Main Results:
- Identified limitations in current standardization: focus on existing categories and narrow examination scope.
- Proposed a strategic framework for comprehensive standardization of pluripotent stem cell technologies.
- Highlighted the potential for leadership in standardization to enhance R&D competence and intellectual property development.
Conclusions:
- A comprehensive and consistent standardization framework is crucial for advancing pluripotent stem cell technology management.
- Standardization can be a strategic tool for improving R&D competence and securing intellectual property.
- The proposed two-stage standardization process (individualization and elemental technology establishment) offers a roadmap for market qualification and compatibility standards.
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