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Related Experiment Video

Updated: Jun 6, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

Putative tissue markers in prostate cancer*.

R Montironi, L Cheng, R Mazzucchelli

    Urologia
    |November 19, 2010
    PubMed
    Summary
    This summary is machine-generated.

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    Identifying reliable prostate cancer markers requires a biological rationale, validated association with disease outcomes, and independent predictive value in multivariate analysis for clinical use.

    Area of Science:

    • Oncology
    • Biomarker Discovery
    • Prostate Cancer Research

    Background:

    • Numerous potential prostate cancer biomarkers exist in various biological samples.
    • These markers show variable effectiveness in detecting cancer and predicting its progression.
    • Rigorous criteria are needed to validate these markers for clinical application.

    Purpose of the Study:

    • To outline the essential criteria for evaluating prostate cancer markers.
    • To emphasize the importance of biological rationale and clinical validation for diagnostic and prognostic markers.

    Main Methods:

    • Review of existing literature on prostate cancer markers.
    • Analysis of criteria for marker validation in clinical settings.
    • Emphasis on statistical validation including multivariate analysis.

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    Last Updated: Jun 6, 2026

    Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
    13:19

    Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

    Published on: November 2, 2013

    Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts
    09:43

    Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

    Published on: August 1, 2025

    miRNA Expression Analyses in Prostate Cancer Clinical Tissues
    11:29

    miRNA Expression Analyses in Prostate Cancer Clinical Tissues

    Published on: September 8, 2015

    Main Results:

    • Prostate cancer markers must have a clear biological or therapeutic rationale.
    • Marker association strength with disease outcome needs thorough assessment.
    • Independent predictive capability in multivariate analysis is crucial.

    Conclusions:

    • Validated prostate cancer markers require a strong scientific basis and proven clinical utility.
    • Meeting these criteria is essential for advancing markers to large-scale clinical evaluation.