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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
Peptic Ulcer Disease III: Clinical Manifestations and Complications01:25

Peptic Ulcer Disease III: Clinical Manifestations and Complications

Duodenal UlcersDuodenal ulcers are the most common form of peptic ulcer disease, presenting with chronic, intermittent epigastric pain. Pain typically appears 2–3 hours after meals, especially when the stomach is empty, often waking patients at night. It is characteristically relieved by food or antacids (“pain–food–relief”). Some patients remain asymptomatic until complications like bleeding or perforation emerge, particularly with NSAID or anticoagulant use.Gastric UlcersGastric ulcers share...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...

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Related Experiment Videos

[Pyoderma gangrenosum: 6 cases].

N El Fékih1, N Kerkeni, M Kharfi

  • 1Service de Dermatologie, Hôpital Charles Nicolle, Tunis, Tunisie. fekih.nadia@planet.tn

Revue Medicale De Liege
|November 20, 2010
PubMed
Summary
This summary is machine-generated.

Pyoderma gangrenosum (PG) is a rare neutrophilic skin disease. This study reviewed six PG cases, finding associations with ulcerative colitis and treating with corticosteroids.

Related Experiment Videos

Area of Science:

  • Dermatology
  • Immunology
  • Pathology

Context:

  • Pyoderma gangrenosum (PG) is an uncommon neutrophilic dermatosis.
  • It is frequently associated with systemic diseases, affecting nearly 50% of patients.
  • Diagnosis relies on clinical and pathological findings, with empirical treatment strategies.

Purpose:

  • To report a retrospective case series of pyoderma gangrenosum.
  • To describe clinical features, diagnostic criteria, and treatment outcomes.
  • To highlight associations with systemic conditions like ulcerative colitis.

Summary:

  • A series of six pyoderma gangrenosum cases (4 female, 2 male, median age 43) over 15 years is presented.
  • Diagnosis was confirmed using established major and minor criteria.
  • Three patients had co-existing ulcerative colitis; all received systemic corticosteroid therapy.

Impact:

  • This case series contributes to understanding pyoderma gangrenosum presentations and management.
  • It underscores the importance of recognizing systemic associations, particularly inflammatory bowel disease.
  • Findings support current diagnostic approaches and the role of corticosteroids in treatment.