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Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jun 6, 2026

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

[Shift work and breast cancer].

G Costa1

  • 1Dipartimento di Medicina del Lavoro Clinica del Lavoro L. Devoto, Università di Milano, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milano. giovanni.costa@unimi.it

Giornale Italiano Di Medicina Del Lavoro Ed Ergonomia
|November 20, 2010
PubMed
Summary
This summary is machine-generated.

Shift work disrupting circadian rhythms is probably carcinogenic. Evidence suggests a link between night work and increased breast cancer risk in women, necessitating further risk assessment.

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Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
09:36

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

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Last Updated: Jun 6, 2026

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
09:36

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

Area of Science:

  • Occupational Health
  • Chronobiology
  • Cancer Epidemiology

Context:

  • The International Agency for Research on Cancer (IARC) classified shiftwork involving circadian disruption as Group 2A, 'probably carcinogenic to humans'.
  • Epidemiologic studies indicate a potential association between prolonged shift and night work and an elevated risk of breast cancer in women.

Purpose:

  • To review the potential physio-pathological mechanisms linking shift work to breast cancer.
  • To discuss challenges in accurately assessing breast cancer risk for female shift workers.

Summary:

  • IARC's classification is based on limited human evidence and sufficient animal evidence regarding light exposure during the biological night.
  • Six of nine reviewed studies suggest a moderately increased breast cancer risk with prolonged exposure to shift and night work.
  • Mechanisms considered include circadian rhythm disruption, clock gene alterations, melatonin suppression, and sleep deprivation.

Impact:

  • Highlights the need for further research into the carcinogenic potential of shift work.
  • Informs occupational health policies and guidelines for shift workers.
  • Emphasizes the importance of understanding and mitigating risks associated with circadian disruption in the workplace.