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Updated: Jun 6, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Functional outcome after thrombolytic therapy.

Sinisa Miljković1, Drasko Prtina, Tamara Rabi Zikić

  • 1University Department of Neurology, Banja Luka Clinical Center, Bosnia and Herzegovina. neurologija@blic.net

Acta Clinica Croatica
|November 20, 2010
PubMed
Summary

Thrombolytic therapy using intravenous tissue plasminogen activator in ischemic stroke patients showed good functional outcomes in over 50% of cases. This treatment demonstrated safety and efficacy comparable to established trials.

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Last Updated: Jun 6, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Ischemic stroke is a leading cause of disability.
  • Thrombolytic therapy, particularly with intravenous tissue plasminogen activator (t-PA), is a critical treatment.
  • Assessing real-world outcomes and safety is essential for optimizing patient care.

Purpose of the Study:

  • To evaluate the safety and efficacy of intravenous t-PA in ischemic stroke patients.
  • To analyze the impact of patient demographics and risk factors on treatment outcomes.
  • To determine functional outcomes at 6 months post-treatment.

Main Methods:

  • Prospective study of 40 ischemic stroke patients.
  • Treatment with intravenous tissue plasminogen activator.
  • Assessment of National Institutes of Health Stroke Scale, Functional Independent Measure, and modified Rankin Scale scores at 6 months.

Main Results:

  • Good clinical outcomes (FIM score >=90 or mRS score <=2) were achieved in 52.5% and 55% of patients, respectively.
  • Symptomatic intracerebral hemorrhage occurred in 5% of patients.
  • Mortality rate was 17.50%.

Conclusions:

  • Intravenous t-PA treatment for ischemic stroke is safe and effective, yielding outcomes comparable to the NINDS t-PA trial.
  • Achieving recommended 'door-to-needle' times is crucial for maximizing therapeutic benefits.
  • Further research into patient-specific factors influencing outcomes is warranted.