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Heterogeneity of rat plasma albumin and drug binding
S Takamatsu1, T Horie, T Mishima
1Department of Biopharmaceutics, Tokyo College of Pharmacy, Japan.
Biochemical Pharmacology
|April 1, 1990
Abstract:
Rat plasma albumin fractionated by Sephadex G-75 (superfine) gel filtration from freshly prepared rat plasma was further separated into three major fractions by chromatofocusing column chromatography. All the fractionated albumins had high binding affinity for the fluorescent probe 8-anilino-1-naphthalenesulfonic acid, as the model compound for acidic drugs, and were found to be immunologically identical.