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Related Concept Videos

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Related Experiment Video

Updated: Jun 6, 2026

Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model
06:04

Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model

Published on: June 9, 2023

Left ventricular non compaction in children.

Sara H Weisz1, Giuseppe Limongelli, Giuseppe Pacileo

  • 1Department of Cardiology, Second University of Naples, Monaldi Hospital, Naples, Italy.

Congenital Heart Disease
|November 20, 2010
PubMed
Summary
This summary is machine-generated.

Left ventricular non compaction (LVNC) is a heart muscle condition with deep recesses in the left ventricle, increasing clot risk. This review focuses on sparse data regarding childhood LVNC cases.

Related Experiment Videos

Last Updated: Jun 6, 2026

Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model
06:04

Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model

Published on: June 9, 2023

Area of Science:

  • Cardiology
  • Developmental Biology
  • Genetics

Background:

  • Left ventricular non compaction (LVNC) is a myocardial disease defined by a hypertrabeculated left ventricular wall.
  • Deep recesses in the myocardium increase the risk of blood clot formation.
  • While adult LVNC is studied, data on childhood LVNC is limited.

Purpose of the Study:

  • To review and summarize current clinical and preclinical knowledge of LVNC specifically in children.
  • To highlight the sparse data available on pediatric LVNC.
  • To consolidate information for better understanding and management of childhood LVNC.

Main Methods:

  • Literature review of clinical and preclinical studies on LVNC.
  • Focus on studies reporting on pediatric populations.
  • Synthesis of findings related to diagnosis, presentation, and outcomes in children.

Main Results:

  • LVNC presents with a hypertrabeculated myocardium, particularly affecting the left ventricular apex and free wall.
  • The condition is likely due to premature interruption of normal heart development, specifically myocardial compaction.
  • Existing research on pediatric LVNC is sparse, necessitating further investigation.

Conclusions:

  • Understanding the developmental origins of LVNC is crucial.
  • Further research is essential to address the paucity of data on childhood LVNC.
  • Consolidating existing knowledge is a key step towards improving diagnosis and management in pediatric patients.