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Device closure of patent ductus arteriosus in Marfan patients: safety and effect on the aortic root diameter

Keyhan S Zanjani1, Abdul Rahim Wong, Masood Sadiq

  • 1Division of Pediatric Cardiology, Pediatric Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Congenital Heart Disease
|November 20, 2010
PubMed
Abstract

Insights

Device closure of patent ductus arteriosus (PDA) is safe for Marfan patients, with no significant impact on aortic root diameter. However, the risk of residual shunts remains a concern even after successful PDA closure.

Area of Science:

  • Cardiology
  • Medical Devices
  • Genetics

Background:

  • Limited data exists on the safety of patent ductus arteriosus (PDA) device closure in Marfan syndrome patients.
  • The effect of PDA closure on aortic root diameter in this population is not well-documented.

Purpose of the Study:

  • To evaluate the safety and efficacy of PDA device closure in patients with Marfan syndrome.
  • To assess the impact of PDA device closure on aortic root diameter in Marfan syndrome patients.

Main Methods:

  • Nine Marfan patients underwent PDA occlusion using coils or Amplatzer Duct Occluder.
  • Patients with aneurysmal and conical ducts were treated with various occluding devices.
  • Follow-up included assessment of aortic root diameter and detection of residual shunts.

Main Results:

  • No adverse events were observed during a median follow-up of 18.5 months.
  • Two patients had small residual shunts post-procedure.
  • A statistically insignificant change in the aortic root diameter to estimated value ratio was noted in patients with complete data.

Conclusions:

  • PDA device closure is a safe procedure for patients with Marfan syndrome.
  • A higher risk of residual shunts exists, even with small duct closures in this cohort.

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