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Related Concept Videos

Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
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Cardiovascular System Abnormal Findings II: Auscultation01:25

Cardiovascular System Abnormal Findings II: Auscultation

Auscultation, an essential part of a heart examination, is done using a stethoscope. It provides crucial information about heart function and possible heart problems. Due to heart problems, abnormal sounds can be heard during systole or diastole. These sounds include S3 and S4 gallops, opening snaps, systolic clicks, and murmurs.
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Disorders of the Autonomic Nervous System

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Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

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Related Experiment Video

Updated: Jun 6, 2026

Wireless Telemetry Device Implantation in a Fontan Ovine Model for Continuous and Long-Term Hemodynamic Monitoring
06:29

Wireless Telemetry Device Implantation in a Fontan Ovine Model for Continuous and Long-Term Hemodynamic Monitoring

Published on: May 2, 2025

Rare problems associated with the Fontan circulation.

David J Goldberg1, Kathryn Dodds, Jack Rychik

  • 1Division of Cardiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, United States of America. goldbergda@email.chop.edu

Cardiology in the Young
|November 20, 2010
PubMed
Summary
This summary is machine-generated.

The Fontan operation offers remarkable survival for complex congenital heart disease but results in "Fontan physiology." This necessitates ongoing research into rare, life-threatening complications affecting multiple organ systems.

Related Experiment Videos

Last Updated: Jun 6, 2026

Wireless Telemetry Device Implantation in a Fontan Ovine Model for Continuous and Long-Term Hemodynamic Monitoring
06:29

Wireless Telemetry Device Implantation in a Fontan Ovine Model for Continuous and Long-Term Hemodynamic Monitoring

Published on: May 2, 2025

Area of Science:

  • Cardiology
  • Pediatric Cardiac Surgery
  • Congenital Heart Disease

Background:

  • The Fontan operation is the final stage in palliative surgery for complex congenital heart disease with a univentricular heart.
  • While technical outcomes have improved, Fontan physiology deviates from normal cardiovascular function, leading to reduced efficiency and increased venous pressure.

Purpose of the Study:

  • To review the implications of Fontan physiology.
  • To highlight the spectrum of rare but serious complications associated with this surgical approach.
  • To emphasize the need for continued research and collaboration.

Main Methods:

  • Review of existing literature on the Fontan operation and its outcomes.
  • Analysis of the physiological consequences of Fontan palliation.
  • Identification of associated complications and challenges in patient management.

Main Results:

  • Fontan physiology results in diminished cardiac output and elevated systemic venous pressure.
  • Patients face risks of hepatic dysfunction, coagulation disorders, protein-losing enteropathy, and plastic bronchitis.
  • Despite high survival rates, complications are complex and multi-systemic.

Conclusions:

  • Fontan palliation achieves significant survival but does not restore normal physiology.
  • Managing rare complications requires a deep understanding of underlying mechanisms.
  • Interdisciplinary and multi-institutional collaboration is crucial for optimizing long-term care for Fontan survivors.