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Related Experiment Video

Updated: Jun 6, 2026

Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma
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Semiautomatic algorithm for lymph node analysis corrected for partial volume effects in combined positron emission

Ralph A Bundschuh1, Markus Essler, Julia Dinges

  • 1Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, Munich, Germany. ralph.bundschuh@tum.de

Molecular Imaging
|November 20, 2010
PubMed
Summary

Partial volume correction (PVC) in positron emission tomography-computed tomography (PET-CT) significantly improves lymph node assessment. This method enhances standardized uptake value (SUV) accuracy, aiding in distinguishing benign from malignant lesions.

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Murine Lymphocyte Labeling by 64Cu-Antibody Receptor Targeting for In Vivo Cell Trafficking by PET/CT

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Area of Science:

  • Nuclear Medicine
  • Radiology
  • Medical Imaging

Background:

  • Positron emission tomography-computed tomography (PET-CT) is a key imaging modality for malignancy evaluation.
  • Limited studies have utilized high-resolution structural data for PET correction.
  • Accurate quantitative analysis of lymph nodes in PET-CT remains a challenge.

Purpose of the Study:

  • To develop and validate a semiautomatic algorithm for partial volume correction (PVC) in PET-CT.
  • To introduce a combined morphologic and functional parameter (multimodal SUV) for lymph node assessment.
  • To evaluate the impact of PVC on standardized uptake value (SUV) and its diagnostic performance.

Main Methods:

  • A semiautomatic algorithm was designed to segment lesions in CT images for PVC.
  • Partial volume corrected (PVC) SUV and multimodal SUV were calculated using CT and PET data.
  • The method was applied to 47 suspicious lymph nodes in 30 patients undergoing 18F-fluorodeoxyglucose-PET-CT.

Main Results:

  • PVC significantly improved lesion uptake measurements in phantom studies.
  • In patients, SUV increased from a mean of 1.29 to 2.8 after PVC (p < .0005).
  • Using an SUV threshold of 2.5, 11 lesions reclassified from benign to malignant post-PVC.
  • Mean multimodal SUV differed significantly between benign (0.39 mL) and malignant (4.47 mL) lesions.

Conclusions:

  • The developed method enables quantitative analysis of lymph nodes in PET-CT.
  • Partial volume correction (PVC) significantly alters SUV values, impacting diagnostic accuracy.
  • The multimodal SUV offers a combined functional and morphologic assessment for lymph node characterization.