Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Catenins01:23

Catenins

Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the adherens...
Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preparation and characterization of visible-light-driven TiO2 photocatalyst Co-doped with nitrogen and erbium.

Journal of nanoscience and nanotechnology·2012
Same author

A novel sucrose phosphorylase from the metagenomes of sucrose-rich environment: isolation and characterization.

World journal of microbiology & biotechnology·2012
Same author

A metal-based inhibitor of tumor necrosis factor-α.

Angewandte Chemie (International ed. in English)·2012
Same author

[Effect of snail control of niclosamide by soil mixing and spraying methods in high dam of terrace].

Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control·2012
Same author

Activation of the CB2 receptor system reverses amyloid-induced memory deficiency.

Neurobiology of aging·2012
Same author

[Down-regulation of transcription factor PU.1 via abnormal epigenetic modification in chronic myeloid leukemia].

Zhonghua zhong liu za zhi [Chinese journal of oncology]·2012

Related Experiment Video

Updated: Jun 6, 2026

Separation of Mouse Embryonic Facial Ectoderm and Mesenchyme
08:36

Separation of Mouse Embryonic Facial Ectoderm and Mesenchyme

Published on: April 12, 2013

Ectodermal Wnt/β-catenin signaling shapes the mouse face.

Bethany S Reid1, Hui Yang, Vida Senkus Melvin

  • 1Department of Craniofacial Biology and Cell and Developmental Biology, University of Colorado Denver, 12801 East 17th Avenue, PO Box 6511, Aurora, CO 80045, USA.

Developmental Biology
|November 20, 2010
PubMed
Summary

Wnt/β-catenin signaling in embryonic ectoderm is crucial for facial development. Manipulating this pathway dramatically alters facial shape and gene expression, impacting vertebrate evolution.

More Related Videos

Assessing Signaling Properties of Ectodermal Epithelia During Craniofacial Development
09:25

Assessing Signaling Properties of Ectodermal Epithelia During Craniofacial Development

Published on: March 24, 2011

Studying Wnt Signaling During Patterning of Conducting Airways
13:00

Studying Wnt Signaling During Patterning of Conducting Airways

Published on: October 16, 2016

Related Experiment Videos

Last Updated: Jun 6, 2026

Separation of Mouse Embryonic Facial Ectoderm and Mesenchyme
08:36

Separation of Mouse Embryonic Facial Ectoderm and Mesenchyme

Published on: April 12, 2013

Assessing Signaling Properties of Ectodermal Epithelia During Craniofacial Development
09:25

Assessing Signaling Properties of Ectodermal Epithelia During Craniofacial Development

Published on: March 24, 2011

Studying Wnt Signaling During Patterning of Conducting Airways
13:00

Studying Wnt Signaling During Patterning of Conducting Airways

Published on: October 16, 2016

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Evolutionary Biology

Background:

  • The Wnt/β-catenin pathway regulates crucial developmental processes.
  • Facial morphogenesis relies on precise signaling networks.

Purpose of the Study:

  • To investigate the role of Wnt/β-catenin signaling in ectoderm during facial development.
  • To understand the pathway's impact on facial patterning and evolution.

Main Methods:

  • Generated conditional β-catenin mouse mutants using ectoderm-specific Cre recombinase.
  • Analyzed facial morphology and gene expression changes (Fgf8, Shh).

Main Results:

  • Ablating or stabilizing β-catenin in embryonic ectoderm caused significant facial morphology changes.
  • Altered expression of Fgf8 and Shh was observed in mutant embryos.
  • The frontonasal ectodermal zone (FEZ) patterning was affected.

Conclusions:

  • Wnt/β-catenin signaling in the ectoderm is essential for normal facial development.
  • This pathway influences key signaling molecules controlling facial patterning.
  • The Wnt/β-catenin pathway may drive the evolution of diverse vertebrate facial shapes.