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Related Experiment Video

Updated: Jun 6, 2026

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient

Published on: September 3, 2014

Genetic dissection of synaptic specificity.

Celine I Maeder¹, Kang Shen

¹Department of Biology, Stanford University, Stanford, CA 94305, USA.

Current Opinion in Neurobiology

|November 20, 2010

Summary

This summary is machine-generated.

Neurons precisely select synaptic partners during development, guided by molecular cues. Recent research reveals mechanisms of this neural wiring specificity, including target selection and subcellular targeting.

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Area of Science:

Neuroscience
Developmental Biology
Molecular Biology

Background:

Nervous systems comprise neurons and synapses, with specific partner selection crucial during development.
Understanding the molecular basis of how neurons choose synaptic partners is an ongoing challenge.

Purpose of the Study:

To elucidate the molecular mechanisms governing synaptic target selection in developing nervous systems.
To explore how neurons achieve precise neural wiring through specific connections and subcellular targeting.

Main Methods:

Review of recent findings on molecular mechanisms of synaptic target selection.
Analysis of positive and negative cues from synaptic partners, intermediate targets, and surrounding tissues.
Investigation of subcellular domain targeting and spatial-temporal transcriptional regulation.

Main Results:

Synaptic target selection involves diverse molecular cues, including guidance signals and repulsive factors.
Synaptic connections are specific not only between neurons but also to defined subcellular domains.
Transcriptional regulation provides versatile spatial and temporal control over wiring specificity.

Conclusions:

Molecular cues and transcriptional regulation are key to achieving precise neural wiring specificity.
Emerging evidence highlights the complexity of synaptic partner selection and targeting mechanisms.
Further research into these mechanisms will advance our understanding of nervous system development.