Related Experiment Video
Updated: Jun 6, 2026
07:34
FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Use of diagnostic testing to detect infertility
Kathleen Hwang1, Larry I Lipshultz, Dolores J Lamb
1Scott Department of Urology, Baylor College of Medicine, Houston, TX 77030, USA.
Current Urology Reports
|November 20, 2010
Summary
Evaluating male infertility is a significant clinical challenge. This review covers current diagnostic tests and future directions for assessing suboptimal semen quality.
Area of Science:
- Reproductive Medicine
- Urology
- Andrology
Background:
- Male infertility presents a growing clinical challenge with substantial emotional and financial impacts.
- Numerous physiological, environmental, and genetic factors contribute to infertility.
- The precise causes of poor semen quality remain largely unknown.
Purpose of the Study:
- To review current diagnostic testing for male infertility.
- To explore future diagnostic avenues for evaluating infertile males.
- To provide guidance for urologists and clinicians in assessing male reproductive health.
Main Methods:
- Literature review of diagnostic tools for male infertility.
- Analysis of current clinical practices in male fertility evaluation.
- Exploration of emerging technologies and research in andrology.
Main Results:
- Current diagnostic methods for male infertility are discussed.
- Limitations in understanding the etiology of suboptimal semen quality are highlighted.
- Potential future diagnostic strategies are identified.
Conclusions:
- Comprehensive evaluation is crucial for infertile males.
- Advances in diagnostic testing are needed to better understand and treat male infertility.
- This review offers a roadmap for clinicians managing male infertility.
More Related Videos
Related Concept Videos
01:23Infertility in Males
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
01:28Infertility in Females
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...
Endometriosis, a condition characterized by abnormal growth of endometrial...
01:24In Vitro Fertilization
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
02:07FISH - Fluorescent In-situ Hybridization
Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...
01:30Serum Laboratory Studies, Stool Test, Breath Test
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
01:30Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...