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Updated: Jun 6, 2026

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Enucleation of the Prostate for the Treatment of Benign Prostatic Hyperplasia Using a 980 nm Diode Laser
Published on: May 5, 2020
New advances in benign prostatic hyperplasia: laser therapy.
Jessica Mandeville1, Ehud Gnessin, James E Lingeman
1Department of Urology, Indiana Clinic/Indiana University School of Medicine, Indianapolis, 46202, USA.
Current Urology Reports
|November 20, 2010
Summary
Holmium laser enucleation of the prostate (HoLEP) offers superior relief for benign prostatic hyperplasia compared to older methods. Newer laser therapies are also emerging for prostate treatment.
Area of Science:
- Urology
- Minimally Invasive Surgery
- Laser Technology
Background:
- Benign prostatic hyperplasia (BPH) is a common condition affecting aging men.
- Transurethral resection of the prostate (TURP) has been a traditional treatment.
- Laser therapies have emerged as a popular alternative for BPH management.
Purpose of the Study:
- To review current literature on laser therapies for BPH.
- To compare safety, outcomes, efficiency, and durability of different laser techniques.
- To evaluate holmium laser enucleation of the prostate (HoLEP) and newer laser modalities.
Main Methods:
- Literature review of studies on laser therapies for BPH.
- Analysis of data on HoLEP, KTP laser, thulium laser, and diode laser vaporization.
- Comparison of urodynamic studies and clinical outcomes.
Main Results:
- HoLEP demonstrates superior bladder outlet obstruction relief compared to TURP.
- HoLEP is as effective as open prostatectomy for large prostates (>100 cc) with less morbidity.
- Newer laser techniques like KTP, thulium, and diode lasers are less studied but available.
Conclusions:
- HoLEP is a well-established and effective laser therapy for BPH in glands of all sizes.
- Emerging laser techniques require further investigation regarding their long-term efficacy and safety.
- Laser therapy offers a range of options for managing benign prostatic hyperplasia.

