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Updated: Jun 6, 2026

Characterization of Glycoproteins with the Immunoglobulin Fold by X-Ray Crystallography and Biophysical Techniques
Published on: July 5, 2018
New insights into the biology and pathobiology of beta2-glycoprotein I
Bill Giannakopoulos1, Peyman Mirarabshahi, Steven A Krilis
1Department of Immunology, Allergy, and Infectious Diseases, St. George Public Hospital, University of New South Wales, Sydney, Australia.
Abstract:
β2-glycoprotein I (β2GPI) is the major autoantigen in the antiphospholipid syndrome. The central importance of understanding β2GPI physiology from the perspective of the rheumatologist is that it forms the foundation for understanding the pathophysiology underlying autoantibody generation, and the diverse mechanisms by which anti-β2GPI antibodies in complex with β2GPI may predispose an individual to the antiphospholipid syndrome clinical phenotype. This review examines some of the latest novel findings in this area.
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