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A cross-species analysis of Satb2 expression suggests deep conservation across vertebrate lineages

Kelly Sheehan-Rooney1, Božena Pálinkášová, Johann K Eberhart

  • 1Faculty of Life Sciences and Dental School, Manchester Academic Health Sciences Centre, Michael Smith Building, University of Manchester, Manchester, United Kingdom. ksr@mail.utexas.edu

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|November 20, 2010
PubMed

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Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...
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Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.The structures that arise from convergent evolution are called analogous structures. They are similar in function even if they are dissimilar in structure. Further, structures can be analogous while also...
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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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