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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

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Related Experiment Video

Updated: Jun 6, 2026

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
07:56

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Published on: April 21, 2017

Neonatal stroke.

L A Ramenghi1, L Bassi, M Fumagalli

  • 1Ospedale Ca' Granda Fondazione Policlinico IRCCS, Milano, Italy.

Minerva Pediatrica
|November 25, 2010
PubMed
Summary
This summary is machine-generated.

Perinatal ischemic stroke, a disruption of fetal or newborn brain blood flow, has three subtypes: arterial ischemic stroke (AIS), cerebral sinovenous thrombosis (CSVT), and hemorrhagic infarct. Early MRI-DWI diagnosis is crucial for effective management and improved outcomes.

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A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
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Last Updated: Jun 6, 2026

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
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Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Published on: April 21, 2017

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
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A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

Area of Science:

  • Neurology
  • Pediatrics
  • Radiology

Background:

  • Perinatal ischemic stroke encompasses heterogeneous conditions affecting fetal and neonatal brain blood flow.
  • Diagnosis can be delayed due to subtle symptoms, despite early onset seizures in some cases.

Purpose of the Study:

  • To define perinatal ischemic stroke and its subtypes.
  • To highlight the diagnostic utility of MRI-DWI and MR-Venogram.
  • To discuss prognostic indicators for neurological deficits.

Main Methods:

  • Review of perinatal ischemic stroke definitions and classifications.
  • Emphasis on Magnetic Resonance Imaging with Diffusion-Weighted Imaging (MRI-DWI) for diagnosis and timing.
  • Utilization of MR-Venogram for diagnosing cerebral sinovenous thrombosis (CSVT).

Main Results:

  • Perinatal ischemic stroke includes arterial ischemic stroke (AIS), CSVT, and hemorrhagic infarct.
  • MRI-DWI is the primary diagnostic tool, identifying acute ischemic lesions in arterial territories (e.g., middle cerebral artery).
  • MR-Venogram detects CSVT and associated complications like intraventricular hemorrhage.

Conclusions:

  • Early and accurate diagnosis of perinatal stroke using MRI-DWI is essential.
  • Lesion extension and involvement of specific brain structures (basal ganglia, thalami, PLIC) correlate with negative prognostic outcomes, including hemiplegia.
  • Timely diagnosis facilitates appropriate management and intervention for affected infants.