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Related Concept Videos

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Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
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Sexually Transmitted Infections

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Related Experiment Video

Updated: Jun 6, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

[Chorioamnionitis in the delivery room].

P Zanella1, G Bogana, R Ciullo

  • 1Dipartimento di Scienze Ginecologiche e della Riproduzione Umana, Università degli Studi di Padova, Italy.

Minerva Pediatrica
|November 25, 2010
PubMed
Summary
This summary is machine-generated.

Chorioamnionitis (CA), an infection affecting amniotic fluid, placenta, and uterus, is common in preterm labor. Early broad-spectrum antibiotics are crucial for reducing maternal and neonatal complications.

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Last Updated: Jun 6, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

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Published on: June 24, 2020

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
04:18

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Perinatal Medicine

Context:

  • Chorioamnionitis (CA) affects 10-40% of maternal peripartum fever cases and 50% of preterm labor cases.
  • Diagnosis relies on maternal fever plus at least two other clinical signs, though histological confirmation is not always definitive.
  • Risk factors include nulliparity, prolonged labor, genital tract pathogens, and frequent vaginal exams.

Purpose:

  • To define chorioamnionitis, outline diagnostic criteria, identify risk factors, and discuss management and complications.
  • To emphasize the importance of early antibiotic intervention in managing chorioamnionitis.
  • To highlight potential maternal and neonatal morbidities associated with chorioamnionitis.

Summary:

  • Chorioamnionitis is an infection of the fetal membranes and amniotic fluid, often diagnosed clinically.
  • Risk factors and diagnostic criteria are established, but histological confirmation can be variable.
  • Early broad-spectrum antibiotic therapy (e.g., ampicillin and gentamicin) is the standard treatment, reducing maternal and neonatal morbidity.

Impact:

  • Early antibiotic administration significantly reduces maternal and neonatal morbidity associated with chorioamnionitis.
  • Prompt management can prevent severe complications such as sepsis, septic shock, and neonatal distress.
  • Continuous fetal monitoring and timely Cesarean section are vital in managing fetal distress in suspected chorioamnionitis cases.