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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes
08:56

Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes

Published on: October 10, 2025

Kikuchi-Fujimoto disease.

Hadar Duskin-Bitan1, Shaye Kivity, David Olchovsky

  • 1Department of Medicine A, Sheba Medical Center, Tel Hashomer, Israel.

The Israel Medical Association Journal : IMAJ
|November 25, 2010
PubMed
Summary
This summary is machine-generated.

Kikuchi-Fujimoto disease, a rare cause of fever and lymphadenopathy, typically affects young women. While often benign, relapses can occur, necessitating consideration in differential diagnoses.

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Multimodality Diagnosis of Mesenteric Ischemia
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Multimodality Diagnosis of Mesenteric Ischemia

Published on: July 21, 2023

Area of Science:

  • Internal Medicine
  • Pathology
  • Immunology

Background:

  • Kikuchi-Fujimoto disease (KFD) is a rare, benign, and self-limited disorder characterized by lymphadenopathy and fever.
  • First described in Japan in 1972, KFD requires careful consideration in the differential diagnosis of febrile lymphadenopathy.

Observation:

  • A retrospective study identified five patients diagnosed with KFD between 2005 and 2008.
  • The patient cohort comprised four women with a mean age of 22.6 years.
  • Clinical manifestations included cervical lymphadenopathy (100%), fever >39°C (80%), splenomegaly (40%), and weight loss (60%).

Findings:

  • Diagnosis was confirmed via excisional lymph node biopsy in all cases.
  • Three out of five patients experienced disease relapse and were treated with steroids or NSAIDs.
  • Kikuchi-Fujimoto disease typically presents with fever and lymphadenopathy, often in young adults.

Implications:

  • Kikuchi-Fujimoto disease should be considered in the diagnosis of young patients presenting with fever and lymphadenopathy.
  • Despite its generally benign and self-limiting nature, the potential for relapse warrants appropriate management strategies.
  • Accurate diagnosis through lymph node biopsy is crucial for appropriate patient care and management.