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Updated: Jun 6, 2026

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
Published on: April 1, 2022
Therapeutic approach and prevention in recurrent acute biliary pancreatitis
Vincenzo Neri1, Antonio Ambrosi, Alberto Fersini
1Department of Surgical Sciences, Division of General Surgery, University of Foggia, Polyclinic Ospedali Riuniti Foggia, Italy. v.neri@unifg.it
Objectives:
Acute biliary pancreatitis (ABP) is caused by alteration of the papillary patency. The normal transpapillar flux and the cleaning of the common biliary duct (CBD) may prevent potentially avoidable recurrent pancreatitis.
Methods:
In the period September 1997/December 2008 we have treated 224 ABP (34 severe, 190 mild/moderate): 162 (72,4%) with the first attack, 62 (27.6%) with recurrent ABP (second or further attack). The patients with recurrent pancreatitis had not undergone, in the previous hospital stay elsewhere, the evaluation and, if necessary, the treatment of the papillary obstacle and/or CBD stones, sludge, etc. In our hospital all patients had undergone the treatment of ABR The treatment was completed with cholecystectomy. All the patients, after the discharge, were introduced in a follow-up program (clinical and ultrasonographic (US) control after 180 days and 1 year).
Results:
In the follow-up of recurrent pancreatitis we have controlled 35 patients (56%-27 lost). The results of the follow-up showed, beside the absence of recurrent acute episodes, the stable normalization of laboratory cholestasis tests and US control. The same controls in 78 patients (48.1%) with a first attack of acute pancreatitis resulted normal in absence of a new acute episode.
Conclusions:
Recurrent ABP have been caused by persistent papillary obstacle. Therefore we confirm therapeutic validity of the instrumental control (US/MRCP) and the possible treatment of papillary or biliary lithiasic obstacle for the prevention of recurrent ABP?
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Acute Pancreatitis II: Clinical Manifestations and Management
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Assessment:
Acute Pancreatitis I: Introduction
Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Chronic Pancreatitis I: Introduction
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...