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Valsartan-amlodipine-hydrochlorothiazide: the definitive fixed combination?
Vivencio Barrios1, Carlos Escobar
1Department of Cardiology, Hospital Ramón y Cajal, Carretera de Colmenar Viejo, Km 9.100, 28034 Madrid, Spain. vbarrios.hrc@salud.madrid.org
Expert Review of Cardiovascular Therapy
|November 25, 2010
Summary
Many patients require multiple medications for hypertension. Fixed triple therapy, combining valsartan, amlodipine, and hydrochlorothiazide, improves adherence and blood pressure control in difficult-to-treat hypertension.
Area of Science:
- Cardiovascular Medicine
- Pharmacology
Background:
- Resistant hypertension often necessitates multiple antihypertensive agents.
- Fixed-dose combinations enhance medication adherence and blood pressure goal attainment.
Purpose of the Study:
- To update evidence on the efficacy and tolerability of a triple fixed-combination therapy for hypertension.
- To evaluate valsartan-amlodipine-hydrochlorothiazide as a treatment option for uncontrolled hypertension.
Main Methods:
- Review of available clinical evidence on the triple fixed combination therapy.
- Assessment of efficacy and safety data from relevant studies.
Main Results:
- The triple fixed combination of valsartan-amlodipine-hydrochlorothiazide demonstrates effectiveness and safety.
- This combination is a rational choice for patients uncontrolled on dual therapy or to improve compliance in those on triple therapy.
Conclusions:
- Triple fixed-combination therapy with valsartan-amlodipine-hydrochlorothiazide is an effective strategy for managing hypertension.
- Improved adherence and blood pressure control are key benefits of this fixed combination.
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