Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of Geographic Atrophy Using a Novel Hyperspectral Gradient Imaging Approach.

Ophthalmic surgery, lasers & imaging retina·2026
Same author

Association of age-related macular degeneration with exposome related metabolomics.

Metabolomics : Official journal of the Metabolomic Society·2026
Same author

Multimodal imaging determinants of contrast sensitivity loss in geographic atrophy.

The British journal of ophthalmology·2026
Same author

Hyperspectral Imaging for the Classification and Analysis of Drusen in Age-Related Macular Degeneration.

Investigative ophthalmology & visual science·2026
Same author

Longitudinal Evaluation of Microvascular Changes and Imaging Biomarkers Associated with Visual Prognosis in Retinal Artery Occlusion.

American journal of ophthalmology·2025
Same author

Correlation between quantitative OCT metrics and contrast sensitivity function in retinal artery occlusion.

The British journal of ophthalmology·2025
Same journal

Longitudinal Structural and Functional Trajectories Following Netarsudil Intensification or Surgical Escalation in Primary Open-Angle Glaucoma.

Seminars in ophthalmology·2026
Same journal

Maternal Diabetes Mellitus During Pregnancy as a Risk Factor for Congenital Nasolacrimal Duct Obstruction in the Offspring - a Large-Scale National Study.

Seminars in ophthalmology·2026
Same journal

Clinical Spectrum and Genetics of Ocular Manifestations in Muscle Eye Brain Disease: A Literature Review.

Seminars in ophthalmology·2026
Same journal

Port Delivery System Vs Monthly Ranibizumab in VEGF-Driven Macular Disease: A Systematic Review and Meta-Analysis.

Seminars in ophthalmology·2026
Same journal

Genome Wide Pleiotropic Analysis Reveals Shared Genetic Architecture and Pathological Basis Between Retinitis Pigmentosa and Relevant Ocular Comorbidities.

Seminars in ophthalmology·2026
Same journal

Does QuantiFERON-Positive Tubercular Serpiginous-Like Choroiditis Affect Retinal and Choroidal Structures Differently in Affected Eyes Compared to Fellow Eyes and Healthy Controls? A Comparative OCT and OCT-A Study.

Seminars in ophthalmology·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
11:20

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

Pharmacologic vitreolysis.

Marc-André Rhéaume1, Demetrios Vavvas

  • 1Retina Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA. marcandre80@hotmail.com

Seminars in Ophthalmology
|November 25, 2010
PubMed
Summary
This summary is machine-generated.

Pharmacologic vitreolysis offers a promising alternative to surgery for retinal disorders. This approach uses intravitreal agents to modify the vitreous, potentially reducing its role in disease pathogenesis.

Related Experiment Videos

Last Updated: Jun 6, 2026

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
11:20

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Vitreous Humor Research

Background:

  • The vitreous humor is implicated in the pathogenesis of various retinal disorders.
  • Pars plana vitrectomy is a common surgical treatment but has limitations.
  • The need for alternatives or adjuncts to surgery has driven research into pharmacologic vitreolysis.

Purpose of the Study:

  • To summarize current knowledge on pharmacologic vitreolysis.
  • To review existing agents and ongoing clinical trials.
  • To discuss vitreous structure and its retinal interactions.

Main Methods:

  • Review of scientific literature on pharmacologic vitreolysis.
  • Analysis of intravitreal agents used for vitreous modification.
  • Examination of ongoing clinical trials and research.

Main Results:

  • Pharmacologic vitreolysis utilizes intravitreal agents to alter vitreous properties.
  • Several agents are being investigated for their efficacy and safety.
  • Ongoing trials are evaluating the potential of these agents in treating retinal disorders.

Conclusions:

  • Pharmacologic vitreolysis presents a promising non-surgical approach for retinal conditions.
  • Further research and clinical trials are essential to establish its role in ophthalmology.
  • Understanding vitreous structure is key to developing effective vitreolytic therapies.